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Interesting article regarding new MS study. It found that T Cells travel via the Lungs in MS patients and bipass the blood brain barrier. A few weeks ago, I read an article about a team looking to diagnose MS via breathing into a tube. They had found that there was something different in the breath of MS patients. I had thought highly unlikely. Now I'm not so sure.

Here is the article and at the bottom is the web link.

"A healthy brain is practically free from immune cells, because the nervous system is separated from the rest of the body via specialized blood vessels that prevent immune cells from entering it from the blood. Up to now it has been unclear how in MS immune cells can overcome this barrier and seemingly pass unhindered into the brain tissue. A research team, initially at the Max Planck Institute for Neurobiology in Martinsried, and later at the University of Göttingen, could now show that these disease-causing immune cells are programmed in the lung to be more motile and to efficiently break through blood vessel barriers

Specialised immune cells, so-called T cells, are held to be the cause of MS. Even though nearly every healthy human harbours potentially disease-causing T cells in his or her immune system, only around 0.1% of the population actually develops a manifest MS. One of the reasons for this is that normally T cells are stopped from entering the brain by a virtually impermeable vascular barrier separating the central nervous 2/3 system from the blood circulation. "Earlier work in experimental MS research showed that when T cells are pre-activated outside nervous tissue they are very well able to pass into the brain and trigger MS-like symptoms there", explains Alexander Flügel, now head of the Department of Neuroimmunology and the Institute for Multiple Sclerosis, University Medical Center, Göttingen. "However, we wanted to find out exactly where in the body these T cells are activated and exactly which properties enable them to overcome the blood–brain barrier." Scientists working at the University Medical Center Göttingen initially discovered that disease-causing T cells cannot enter the brain immediately after activation but rather have to "learn" how to do so. During this learning process the T cells completely re-gear themselves. They stop dividing and throttle their production of proteins that foment inflammation. Instead they are programmed for migration: they become more motile, and specialized receptors appear on their surface membranes. These receptors are like little antennae that enable a T cell to orientate itself by picking up signals from its environment and to cleave to surfaces. The Göttingen scientists discovered that the receptor Ninjurin 1, previously unknown to have any relevance to T cells, controls the ability of T cells to cleave to the inner side of the brain's blood vessels and thus is of great significance for the migration of T cells from the blood into the nervous tissue. Once the T cells arrive in the nervous tissue, this program goes into reverse: the immigrant T cells are reactivated and they produce inflammatory mediators that set the tissue-damaging autoimmune processes in motion typical to MS.

But where in the body are the T cells programmed for migration? The Göttingen scientists could also make new, unexpected discoveries on this question. They found out that activated T cells migrate directly from the circulation into the lung. Once in the lung tissue the cells move forward with increasing speed along its blood vessels and airways to reach the adjoining lymph nodes from where they re-enter the blood circulation and spleen and ultimately invade the nervous system. Curiously, when in the lung the T cells do not only creep along the outer surface of the bronchial tubes but also crawl briskly along the inner surfaces of the airways where breathing air is circu-lated. Using a special microscopic technique the researchers could observe in living lung tissue the T cells using the bronchial tubes as a kind of highway. And indeed, when activated T cells are introduced directly into the airways they are able to set an autoimmune disease process in motion. It is also here in the lung where the first decisive steps take place towards programming the disease-causing T cells into a migratory mode. The direct relevance of these results to the human disease MS lies in the possibility that infections of the respiratory tract and/or lung irritants, e.g. smoking, can trigger disease attacks. The scientists of this study discovered potentially autoaggressive T cells dwelling long-term in the lung as immunological memory cells. When stimulated locally, these "sleeping" cells became active: They migrated to the brain and triggered off an MS-type disease there. The key role of the lung in activating and reprogramming disease-causing T cells could also be valid for other organ systems such as the gut or urinary tract, though perhaps less dramatically. Recent comprehensive genetic analyses could identify various genes in persons suffering from MS that made these persons more susceptible to the disease. "Interestingly, a significant number of these genes were the same as those found in the current study to be involved in the migratory programming of T cells", says Alexander Flügel. The aim of further studies will therefore be to find genes from the migratory programming that are suitable as therapeutic targets. More information: Francesca Odoardi, et al. T cells become licensed in the lung to enter the central nervous system. Nature (2012) 488: 675-679, doi: 10.1038.nm.2629Journal reference: Nature "

http://medicalxpress.com/news/2012-09-m ... emote.html
Here is a link to that article I mentioned earlier regarding how a Chemical Sensor May Help Diagnose and Track MS by breathing into a tube.

http://medgadget.com/2012/08/chemical-s ... ck-ms.html

All very interesting.

Janet (NJ)
Thanks for sharing! Fascinating study
I've moved this topic to Miscellaneous.
Wow. It makes me wonder about that mould patch in my old room too. It explains the smoking connection.
Alex

Diagnosis: Jan 2010, OMS April 2010.
Wow indeed. Mildew can be insidious. I saw a recommendation to " sneak up on it" so you don't distribute it further when you clean it. It amuses me. This weekend I'll call in the pink panther to tiptoe in from behind to spring clean any suspects.

My dx was preceeded by bronchitis and sinus. Would it help to swim to build lungs? I swim like a pebble.

This promoted me to search lung irritants
http://eartheasy.com/blog/2010/05/copd-–-it-can-take-your-breath-away/

Some handy tips how to safely treat potential lung irritants:
http://www.youtube.com/watch?v=iO_eXXgO ... ata_player
http://www.youtube.com/watch?v=qobWkHxe ... ata_player

House plants http://eartheasy.com/blog/2009/05/the-t ... or-toxins/

I recall someone mentioning formaldehyde / ammonia, saying avoid wood fires, tinned fruits and tomatoes ( slow cook them a few hrs with lid off and room vented) which I didn't want to hear as we get so many suspicions, but perhaps there's a link due to respiratory irritation
http://eartheasy.com/blog/2009/12/forma ... -the-home/
That's amazing!
Dx 1992 OMS 25-2-09
Yes, it's amazing. But it's unlikely that any one factor is going to be found responsible for MS.

I think the keys to success lie in the Mind/Body approach to disease control: What we think affects every cell in our body.

Why do PwMS have/develop such renegade cells? Do our belief systems cause us to self-destruct at a cellular level?
Cheers,

Sue

OMG December 2011 OMS January 2012 OMS Retreat March 2012 Benign MS Sep 2015
Two Very Mild Relapses since diagnosis. Copaxone May 2013 No new lesions on MRI since diagnosis
Does anyone here have or had allergies or breathing difficulties?

I didn't have allergies when I was little, but I was always irritated by smells as if I couldn't breathe. Driving into Philadelphia when I was a child in the 1970's, before pollution control went into effect, made me feel like my lungs were heavy and made my body tense up. Same thing around paint, etc....

Then in college I had a sulfite (preservative) allergy pop up. It was to the point of being rushed to the hospital on several occassions and having to carry around an epinepherine shot. However, then I had a few spiritual things happen in my life and other magnificant synchronicities that led me to being a vegan and within a year my sulfite allergy was gone and my nature was much calmer.

I have read a few articles based on the premise that allergies occur at a higher rate in those who are anxious/stressed/on-edge. The question is whether it's because someone is anxious that they have the allergies (for example, their muscles are tighter and their physical system in general is more constricted) or is it that allergies cause us to be stressed and more anxious. There have been examples of people with split personalities where one of their personalities has no allergies and another has severe allergies with hives and breathing difficulties while eating the same exact foods.

Here in my mid 40's, I am in no way near as tightly strung as I was as a child. As a child I was extremelly tightly strung and anxious. If you said "boo" to me I would have jumped. Friends now would say I am very laid back, centered, calm, peaceful. I no longer have any allergies.

I know many here wonder if our childhood trauma's have an impact on MS developing in the first place. When I was 4, 5 and 6 years old, I had a psychotic babysitter who would rape me. I would be awakened from sleeping to the horror. From then on, I would jump at anything. I couldn't sleep for fear someone would come in and hurt me. I wanted to be perfect in order to not be hurt by anyone again. Of course as a child, one believes they have some innate flaw in order for such things to happen and also the belief that one is tainted by such experience. I had bronchitis many times as a child.

However, I have healed and grown out of the tradgedy. I believe such events make us more sensitive and consciencious of others' trials. I wonder if this abuse which absolutlely made me high strung and tight in how I held every part of my body (from breathing to circulation to lungs) contributed to my allergies/breathing issues.

It makes me wonder if the abuse can be one of the triggers for MS. And it wouldn't have to be rape, it could be an angry or alcoholic parent or feeling bullied to an extreme. It just seems like there is a thread running through this somewhere between childhood trauma, being anxious, breathing issues, and MS. And then the correlation to the success that mindfulness meditations have on relieving MS symptoms. As Dr. Jelinek has pointed out, there have been studies that support Mindfullness Meditations succes with regards to MS symptoms. Meditation relaxes every part of my body.

Just something to ponder. :D (The smiley face may seem out of place here to some, however, I can discuss this topic and still allow the happy healthy person and inner soul that is within to shine. At this stage, I am who I am, it happened, but it doesn't impact my happiness today. Occassionally, I re-explore parts with my therapist as triggers come up. However, for the most part, I am one of those perky happy people that drive curmudgions crazy.)

I wish happiness, laughter, and living life according to who you truly are - with adventure and a slight reckless abandon, enjoying each moment to the fullest for each and every one of you.

Janet (NJ)
We have to be so careful not to go crazy - at least I do.

Shortly before my first attack of ON:

1) I was smoking
2) I was having extreme stress at a new job after moving from another country, separated from my family
3) I found someone spraying pesticides in my room one day (it was a furnished business room)

Before my 2nd attack

1) Horrible mold behind my bed
2) Work stress
3) Family stress

So I wonder about all of them but address them through healthy living and avoiding stress. I had my lung function tested for the first time in 5 years. Before, I had the lungs of a 51yo. Now I was off the charts - like an 18yo.
Alex

Diagnosis: Jan 2010, OMS April 2010.
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