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Has anyone seen any studies that recommend specific types of probiotics? There are many different strains of bacteria listed for the refrigerated probiotic capsules at the health store. Lactobacillus seems to be a common denominator...
Can someone recommend a specific probiotic supplement? Many thanks.
The article below might be relevant:

A Novel Probiotic Mixture Exerts a Therapeutic Effect on Experimental Autoimmune Encephalomyelitis Mediated by IL-10 Producing Regulatory T Cells
Shahram Lavasani, Balik Dzhambazov, [...], and Björn Weström

http://www.ncbi.nlm.nih.gov/pmc/article ... n_sectitle

The article reports on a study where mice were given Experimental Autoimmune Encephalomyelitis (EAE - the mouse equivalent of MS) and then treated with various strains of lactobacilli. After initial screening, three Lactobacillus strains, L. paracasei DSM 13434, L. plantarum DSM 15312 and DSM 15313 were chosen. The article goes on to say that "further screening of the chosen strains showed that each monostrain probiotic failed to be therapeutic in diseased mice, while a mixture of the three lactobacilli strains suppressed the progression and reversed the clinical and histological signs of EAE. "

Which suggests that we dose ourselves with a mix of the Lactobacillus strains:

L. paracasei DSM 13434,

L. plantarum DSM 15312 and

L. plantarum DSM 15313

The study treated animals both with live and with heat-killed bacteria and the article goes on to say that ". . . a presence of live bacteria in the gut seems to be essential for their immunomodulatory effect since the killed bacterial strains used in our study had no suppressive effect on diseased animals. "

Which does make me wonder if refrigerated capsules in health stores represent a viable source of live bacteria? The authors of the above article mention bacteria (sourced originally from the guts of healthy humans) being delivered from a lab throughout the course of the study. My own overriding memory from being practical assistant on a faecal material transplant exercise was the need for speed, rushing to ensure that a maximum of 30 minutes elapsed between "donation" and "delivery" (see the posts under "Love your gut" for full (gory) detail) so that the bacteria remained live and viable of colonising the gut of their new host.

A 2014 study into the efficacy of probiotic products appears to suggest that these are best taken on an empty stomach:

http://www.nutraingredients.com/Researc ... cacy-study

This is a really interesting topic, and one that amply deserves more time and effort. I'll post again if I unearth anything worth sharing!

The Gut Microbiome is KEY to optimal health.
The OMS site & forum are brilliant! Thanks, everyone! :D
This interview with microbiologist Kiran Krishnan, which appears on the crohns.net website, contains some interesting information:
Seven surprising facts about Probiotics
https://www.crohns.net/blog/scientific- ... robiotics/

And when it comes to choosing a probiotic product, It looks as if crohns.net asked PeakBioctics, the company Kiran Krishnan works for) to develop some probiotics that actually worked. Apparently they collaborated with the Microbiology Department at Royal Holloway In London to develop the product below:
Perfect Pass Probiotic news release
https://www.crohns.net/blog/perfect-pas ... an-strain/
The Gut Microbiome is KEY to optimal health.
The OMS site & forum are brilliant! Thanks, everyone! :D
The text below appears on the Multiple Sclerosis News Today website. The probiotic that Harold Weiner gives to his MS patients is VSL3, available without prescription in the US from pharmacies or on https://vsl3.com

Harold Weiner, MD, believes in using probiotics to help treat multiple sclerosis. He is such a believer that he did a presentation on the subject — “Probiotics in Multiple Sclerosis” — at the just-concluded Americas for Treatment and Research in Multiple Sclerosis (ACTRIMS) 2017 Forum in Orlando. The event ran from Feb. 23-25.

Weiner, who is with the Partners Multiple Sclerosis Center at Harvard University’s Brigham and Women’s Hospital in Boston, began his presentation by noting that our intestine is linked to our central nervous system via the vagus nerve, the circulatory system and our immune system. Then he explained how the gut microbiome can cross the blood-brain barrier to reach the nervous system, where it can cause problems that lead to MS.

He has studied the gut in people with MS and healthy controls via fecal samples — the usual way to study the gut — and with blood serum collection and Breathalyzer tests.

People are less resistant to a Breathalyzer test than collecting a stool sample, he said, so Breathalyzer tests may become a key diagnostic tool someday. For now, he still collects fecal samples from almost all his MS patients.

Weiner offered this summary of findings from his research on small populations of MS patients:

- Methanobrevibacter and Akkmansia, microbes in the gut that drive pro-inflammatory processes, are increased in MS.
- The Butyricimonas bacteria is decreased in MS.
- Probiotics help increase the gut’s levels of butyrate, a substance that mediates inflammation.
- MS patients had increased levels of methane in their breath, an indication of digestive problems.

Most of us might not understand these terms. I had to search to find that methanobrevibacter is important in the digestion of sugar, while akkmansia has a role in diabetes and obesity. Both could be a factor in MS, as well as in our overall well-being.

Weiner suggested that the disease-modifying therapies (DMTs) used to treat MS may act. in part. in the gut. The gut’s role in MS may offer new chances for treating it, he added. One would be modulating the gut through the use of probiotics. Another would be introducing specific bacteria — yet to be identified — that could combat MS.

Weiner already includes probiotics in his treatment of people with MS. They are non-toxic and can positively affect the gut microbiome, he said.

He prescribes probiotic VSL#3 for his MS patients. Animal models have demonstrated it is useful in diabetes, colitis and allergies, and it has helped humans with irritable bowel syndrome and ulcerative colitis, he said.

Weiner said he has taken VSL#3 himself, although he didn’t mention if it was part of his regular routine. VSL#3 has 450 billion bacteria per packet, and is officially listed as a medical food. That means you don’t need a prescription to buy it, but it should be consumed under the advice of a medical practitioner.

In a pilot trial of probiotics’ effects on MS, Weiner gave a small cohort — nine people with MS and 13 controls — VSL#3 for two months. Blood and stool samples were collected before the participants began treatment, at the end of the therapy, and three months later.

Weiner found that VSL#3 improved MS patients’ gut microbiota composition. In particular, it decreased the number of inflammatory monocyctes — a type of white blood cell — in the gut. The number of inflammatory monocytes increased again after the patients stopped taking VSL#3.

Weiner’s talk was one of several oral and poster presentations at ACTRIMS 2017 that focused on the relationship between the gut and multiple sclerosis. Researchers said the approach shows promise for treating the disease and should encourage more research in this area.
The Gut Microbiome is KEY to optimal health.
The OMS site & forum are brilliant! Thanks, everyone! :D
I've heard dubious reports about some of the probiotics you buy in health food stores. I eat cultured vegetables, full of probiotics and also don't forget prebiotics! That's what the little microbes eat. Fibrous fruits and veg help. Also kefi or kombucha are great, easy to make and excellent source of beneficial bacteria. Just be careful not to buy anything raised on dairy.
Diagnosed August 2015
OMS November 2015
OMS Retreat May 2016
Jette, absolutely a wonderful suggestion. Really thank you. It is crystal clear the connection between microbioma and nervous system (leaky gut, Th1-17-2-reg balance and so on... even Candida if you think about it). Indeed, I have recently started to make in depth analysis but it was difficult to find safe and effective strains, because some strains seem to enhance autoimmunity. For this reason, I have look up the strains used in the study already posted in this topic and now I'm taking it (bough on Amazon). But now, thanks to you I see that a neurologist believer in microbioma-nervous system connection prescribes this specific mixture of strains... wonderful. Thanks again

As LadyBug said take care of prebiotics. If you eat plenty of vegetables it is absolutely unuseful to take supplements.

One question for you: do you take probiotics on empty stomach? It seems that we are better off taking them while eating, because good bacteria would be overly exposed to low gastric pH and also because they need nutrients to survive in our digestive system.
I am glad you found the post(s) useful! To deal with your question first, I am fairly confident that it is best to take probiotics WITH food, as you rightly conclude.

I also agree with LadyBug's point about maintaining a healthy skepticism when it comes to paying out money for pre- and pro-biotic products. They represent a multi-billion pound industry and there are lots of people who are only too happy to take our money in exchange for worthless products. As LadyBug says, we CAN make our own probiotic drinks and foods (kombucha, kefir, sauerkraut etc etc) and this is clearly a sensible long-term strategy. But I also believe there may well be a case for kick-starting the process of healing our guts with a good pro-biotic product.

The strain I have chosen to try is Bacillus clausii, made by the Italian company Sanofi and marketed under their Enterogermina label. They have several products that all carry the Enterogermina label so it"s important to check the small print. Bacillus clausii is sold as a liquid suspension in packets of 20. Each 5ml dose contains 2 million Bacillus clausii. One takes a 5ml dose 3 times a day - dissolved into a bit of liquid and taken with food - for 4-6 weeks and then continues a maintenance dose of 5ml a day.

My rationale for going for Bacillus clausii goes as follows:
- 60% of our nervous system is controlled by our gut.
- proponents of functional medicine hold that everyone with an autoimmune disease has a leaky gut
- Microbiologist Kiran Krishnan relates a research exercise where a group of supposedly healthy students were given a highly inflammatory meal (a McDonalds breakfast burger). Their blood serum was then checked. 65% of the turned out to have a leaky gut. They were given spore probiotics for a month and the fed same inflammatory meal. No leaky gut. https://www.youtube.com/watch?v=oG4_6NMmG4Y
- Kiran Krishnan mentioned three different spore probiotics. Of the three, further reading suggested that B. clausii might be the most promising.

Enterogermina is available to buy without prescription in Italy, where it has been freely available for 60 years. It should also be available to buy over the counter in the US. It is not licensed in the UK for some reason, so I had to order it from Italy:
http://www.farmacia-ciarcia.it/en/farma ... results=12
The Gut Microbiome is KEY to optimal health.
The OMS site & forum are brilliant! Thanks, everyone! :D
I'm from Italy and Enterogermina is definitely the most renowned probiotic... even my grandmother when there is someone with a bellyache " you must take Enterogermina! " :D
I am using Bio-Kult (from Amazon) which is a multi strain formula.each capsule contains 2 billion micro organisms and supposedly proven to survive stomach acid.....
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