I started tecfidera but have discontinued it due to unlisted side effects - but a lot of people seem to tolerate it well. It would seem that this is the best of a bad bunch in terms of efficacy and side effects.
Having looked into all ms drugs, I've decided for the time being to try to get onto low dose naltrexone as an off label treatment used for some neurological and auto immune illnesses - which has a lot of anecdotal success with little in the way of side effects. But where it is cheap and generic now, there's no money for big pharma to make and study in greater clinical trials.
There's no way I'd go onto most of the DMDs, for the side effects, rebound effects, infection risk and developing other auto immune diseases...sheesh, how these ever got into the healthcare system is beyond a joke, except for perhaps the worst MS cases.