Just thinking about the gut a bit more...extreme naval gazing 2.0, haha. I am a total layman with medicine, and have been contemplating things I don't even superficially understand really, so here it goes.
First of all, I find it confusing that if the immune system in a PwMS is confused by milk proteins, why is there a delay until the nervous system for an attack? In other words, why does the immune system not go straight for the proteins in the gut, like what's seen in Celiac disease with gluten?
Could it mean there is a barrier that has been destroyed in the gut in a person with Celiac disease but not in other autoimmune conditions? Could this be a microbe-gut barrier that has lost integrity in a person with Celiac (like "leaky gut," another thing I don't understand, but different somehow because again, why wait for the nervous system)? I have read that there is also a nerve-blood barrier for the peripheral nervous system that is compromised with CIDP which is like the peripheral version of MS.
Moreover, the immune system has to be "trained" when we are young, but are autoimmune conditions the result of improper training or a matter of faulty barriers or both? Is it possible to identify breached barriers (of different forms) for all systems compromised by autoimmune disease within the body? Then when one barrier is breached is it subsequently easier to breach another barrier, i.e. the increased chances of acquiring an additional autoimmune disease if one already has one?
What is the role of gender and hormones from this angle?
With C-sections, could it be that once you start down that road that it is somewhat of the same principle as bioaccumulation of toxins up the food chain, altering genetic integrity one layer at a time, but in this version rather a bio-decumulation of the good, co-evolved, intact bacteria we need passed down from generation to generation with its own unique genetic integrity? It is interesting that we are seeing an increase in C-sections and the use of antibiotics in tandem with autoimmune disease, but I don't think people who can trace MS in their family to, e.g. their grandma's third cousin can also say that there was a C-section in the picture that also relates to them necessarily? Or is it a complex puzzle of susceptibilities that together increase risk?
Preponderance of provincial ponderings...