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Hi all,

I went to an integrative Dr. yesterday after getting an ELISA test. Fortunately the test showed that I had minimal food sensitivities (the only "severe" one was to amaranth, although almonds also came up, which was a bummer). Anyways, the Dr told me to take L-glutamine (in addition to digestive enzymes and a probiotic) 1-2 per week for 6 months to help heal the mild leaky gut that I may have. MS-Direct however, has an article on how glutamine supplementation may be bad for MS (http://www.direct-ms.org/pdf/NutritionM ... mineMS.pdf). I was wondering if anyone had heard anything similar, or had any experience with L-glutamine and healing leaky gut.

Thanks in advance!
I am really glad you raised this issue. After being exposed to the proposition that everyone with an autoimmune disease has a leaky gut, I had myself been looking into how to heal my insides. Glutamine supplementation seems to come high up the list pretty well universally. Delving a bit deeper - as you very sensibly did - does indeed suggest that glutamine supplements might not be ideal for people with MS. If your integrative doctor cannot suggest an alternative, perhaps you could keep the daily doses as low as possible. Some of the sites I read suggested that a daily maximum of 5-10g should be ok for PwMS, while others said we were better off avoiding it altogether.

I"ll post again if/when I find some good links to pass on.

Jette
The Gut Microbiome is KEY to optimal health.
The OMS site & forum are brilliant! Thanks, everyone! :D
I saw a nutritious a while back that recommended glutamine for a leaky gut then she quickly corrected herself when she remembered I have MS. She said it's a neuro stimulant and wouldn't recommend it for someone with MS. I didn't look into it myself just took her word for it.
@ Jette: I had also seen some sites that suggested that 5-10g of L-glutamine should be ok, but then others with conflicting info....not sure what to think!

@ rafticon: Did the nutritionist recommend an MS-safe alternative to L-glutamine?
In no particular order, here are a few things I came come across in connection with healing a leaky gut:

Someone who wrote in to the Amy Myers site to ask about alternatives to L-Glutamate (on the grounds of MS) was advised to try a product referred to as Great Lakes Collagen.

In a video interview about autoimmune disease and the gut, Michael Ash (practitioner of functional medicine) recommended eating two stewed/cooked apples a day. They needed to be cooked with some skin on, as it is the pectin that is supposed to have a healing effect on the gut. No sugar, but OK to add a few raisins for sweetness. Adding some (anti-inflammatory) cinnamon also recommended.

In the short video interview below, microbiologist Kiran Krishnan relates how a group of supposedly healthy students were given a highly inflammatory meal. Blood samples were then taken and the presence of toxins in the blood showed that 65% of of them had a leaky gut. The sample group was then given spore probiotics for a month and fed the same highly inflammatory meal (a MacDonalds breakfast burger!)and their blood re-tested. Apparently none of them then had any toxins in the blood. The inference is that the spore probiotics had worked to seal the gut.

https://www.youtube.com/watch?v=oG4_6NMmG4Y

Looking into spore probiotics, an interesting strain would appear to be Bacillus clausii. More information here:

http://www.powerofprobiotics.com/Bacillus-clausii.html
The Gut Microbiome is KEY to optimal health.
The OMS site & forum are brilliant! Thanks, everyone! :D
Thanks for all of the info Jette! You've really done your research! I'll take a look into some of those suggestions. Have you been treating your leaky gut/what sort of results have you been getting?
Hello again rjakal,

After I mentioned the collagen supplement the other day it occurred to me that the (fish-) bone broth recommended both on the Dr Axe website and by fellow OMSer KeithjVaz would probably do the same job? I remember Keith writing that one needed to cook the fish ones right down, to get everything out of them.

I am indeed trying to be good to my own gut but am at the very early stages of working out how to go about it and my efforts are most likely rather random! I will do a post about my endeavours within the next few days.

Good luck with your own efforts.

Jette
The Gut Microbiome is KEY to optimal health.
The OMS site & forum are brilliant! Thanks, everyone! :D
rafticon wrote: I saw a nutritious a while back that recommended glutamine for a leaky gut then she quickly corrected herself when she remembered I have MS. She said it's a neuro stimulant and wouldn't recommend it for someone with MS. I didn't look into it myself just took her word for it.



I have been delving into all things leaky gut and how to manage LG in the context of MS. L-glutamine was recommended to me, however I undersand that L-Glutamine and Glutamate are along the same spectrum (https://en.wikipedia.org/wiki/Glutamate-glutamine_cycle). Articles such as https://www.ncbi.nlm.nih.gov/pubmed/28236206 indicate that Glutamate excites neuro-transmitters, which is what some of the MS treatments are trying to settle!

I am going to do some more research into L-glutamine, its effect on leaky gut and if there is anything that can be used in its place for conditions that Glutamate is not appropriate for.

(I am finding water kefir, kombucha, collagen and probiotics a good start, just need to refine my approach, but there is a lot of info out there!)
I tried 1g l-glutamine and had slight MS symptoms (enough to make me wary, I will keep trying at a lower level). however further research has brought me across 'Restore' (https://shop.restore4life.com/) and (https://au.iherb.com/pr/Restore-For-Gut ... lsrc=aw.ds)

Restore doesn't contain any l-glutamine and I am reading more into it and whether it contains anything that might interact with MS drugs or MS mechanism (as l-glutamine appears to).

I also found
https://www.highya.com/restore-reviews
https://www.curezone.org/forums/am.asp?i=2052155
https://eatbeautiful.net/2015/12/28/glu ... leaky-gut/
https://www.ncbi.nlm.nih.gov/pubmed/23613944
http://www.alternativemsrecovery.com/ar ... leaky-gut/
the information at the link https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307240/ appears to say that Quercetin and Curcumin settle neurotoxicity while sealing the gut lining.


Could be promising as an alternative. I would be interested in other thoughts.
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