Last paragraph in the Program Summary/vitamin D: http://www.overcomingmultiplesclerosis. ... Vitamin-D/
"For people with initial levels indicating severe deficiency less than 12.5nmol/L a one-off megadose of 600,000IU raised levels to an average of 73nmol/L. This is still probably half the level which may be optimal in MS, but it can be seen that even large doses of this vitamin are quite safe. More recent research has shown that people who are overweight or obese require even larger doses of supplements to get levels up. My suggestion is to get a one-off dose like this if the initial level is low, and then take a regular supplement of around 5,000IU a day in winter, or more if required (10,000IU a day is perfectly safe), and the same on summer days when you get no sun, to get the level to around 150nmol/L as a minimum. The level should be checked at the end of each winter of supplementation to make sure it is not being overdone. Holick, a world authority on vitamin D suggests annually checking oneâ€™s vitamin D level as a routine."
This logic implies your level of 45 nmol/L would go up by around 60 to 105 with the first massive dose. At the retreat George said there was an initial risk of fractures with very high doses, however even large doses are safe.
In my case, my initial level was 85. A megadose of 150,000 took me over 170nmol/L and 7000 a day has nudged it up to 210 and kept it there. I have been getting sun too.You will only know for sure with regular blood tests.