Teriflunomide

Teriflunomide (trade name Aubagio) was approved by the US FDA in 2012 for the treatment of relapsing forms of multiple sclerosis. It is taken daily as a tablet.

Teriflunomide (trade name Aubagio) was approved by the US FDA in 2012 for treatment of relapsing forms of MS.

It is taken as a tablet once daily. While its exact mechanism of action is unknown, it reduces the number of immune cells involved in the MS response (it is known to reduce proliferation of lymphocytes by blocking a certain enzyme).

Side effects

Common side effects include upper respiratory tract infections, urinary tract infections, nausea and vomiting, paresthesia (pins and needles), hair loss and abnormal liver enzymes (indicating liver damage).

Teriflunomide is the active metabolite of leflunomide, which is used in the treatment of inflammatory arthritis.

A large US observational study found an increase in skin cancers (including melanomas). Post-marketing cases of lymphoma have been reported. Severe liver damage is thought to occur in 0.5% (including fatal outcomes) and cases of interstitial lung disease have been reported.1-3

 Because we have limited experience to date with the use of teriflunomide, it is important to consider the side effects of the parent drug and the potential that these may also apply to teriflunomide.

Those taking leflunomideare are advised to avoid alcohol, live viral vaccines, and other drugs that affect the immune system.

Teriflunomide Trials  

Teriflunomide itself has been the subject of a number of drug company-funded randomized controlled trials. The first of these, the TEMSO (Teriflunomide Multiple Sclerosis Oral Trial), was published in 2011 in the New England Journal of Medicine. It studied 1,088 people with MS who were randomly assigned to either placebo or 7mg or 14mg of teriflunomide and then followed for 108 weeks. Drop-out rates were around 30% for all 3 groups. The primary outcome measure was annual relapse rate: there was around a 30% reduction in annual relapse rate in both treatment groups, with a trend for reduced disability progression in the treatment groups, although these differences weren’t significant. There was no difference in fatigue levels between the 3 groups.4

Studies into Teriflunomide

In 2012, Freedman published a study investigating the safety and efficacy of teriflunomide as an add-on therapy to interferon beta.

A group of 188 people with MS received either IFN plus teriflunomide or IFN plus placebo. The initial study was for 24 weeks, and participants had the option to continue for a further 24 weeks. There were lower relapse rates in the teriflunomide groups, but these were not significant; however, there were significantly fewer lesions on MRI scanning in the teriflunomide treatment groups.5

All studies of teriflunomide in MS have been reviewed by an independent Cochrane review. Its authors were ‘unable to give any clear recommendations for the use of teriflunomide as a disease-modifying therapy for MS because the studies had limited quality, were of short duration and were funded by a pharmaceutical company.

They added that there is ‘low-level evidence for the use of teriflunomide as a disease-modifying therapy for MS due to the limited quality of the available randomized controlled trials. However, both teriflunomide 7mg and 14mg have potential benefits, alone and with add-on interferon beta 1a, and the review shows it to be safe for patients with relapsing forms of MS in the short term.’

The authors cited concerns over the high dropout rates in both studies, although these were lower than in studies of many other MS drugs.

In the Freedman study, they cited a lack of information about why people dropped out, as well as a lack of clarity over how participants were randomized into groups, what the criteria were for excluding people for the trial extension, and how this was blinded. This information was requested by the Cochrane reviewers but not provided by the researchers or by Sanofi (the company sponsoring the trial).6

Pregnancy

It is also important to note that Aubagio has been shown in animal studies to significantly increase the risk of fetal abnormality, and the manufacture advises avoiding pregnancy for 2 years after stopping the drug

As many with MS will be females at the stage in their life when they are considering starting a family, this significantly limits its use.


References

  1. Chikura B, Lane S, Dawson JK. Clinical expression of leflunomide-induced pneumonitis. Rheumatology 2009;48:1065-1068 
  2. Inokuma S. Leflunomide-induced interstitial pneumonitis might be a representative of disease-modifyingantirheumatic drug-induced lung injury. ExpOpin Drug Safety 2011;10:603-611 
  3. Savage R L, Highton J, Boyd IW, Chapman P. Pneumonitis associated with leflunomide: a profile of New Zealand and Australian reports. Int Med J 2006;36:162–169 
  4. O’Connor P, Wolinsky JS, Confavreux C, et al. Randomized trial of oral teriflunomide for relapsing multiple sclerosis. N Engl J Med 2011;365:1293–303 
  5. Freedman MS, Wolinsky JS, Wamil B, et al.Teriflunomide added to interferon- β in relapsing multiple sclerosis: A randomized phase II trial. Neurology 2012;78:1877–85
  6. He D, Xu Z, Dong S, et al. Teriflunomide for multiple sclerosis. Cochrane Database of Systematic Reviews 2012, Issue 12. Art. No.: CD009882
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