The Coimbra Protocol promotes using high-dose vitamin D to treat MS and claims to have seen good results. Vitamin D has been linked to MS prevention and is known to offer health benefits, and the dose of 1,000 IU per day recommended under the protocol can help the body to function optimally. However, although many people with MS use the Coimbra Protocol treatment (which has to be given by a professional), there is no known medical evidence backing it up.

Vitamin D

If you have MS it is important that you know about the connection between vitamin D and your health. We include it as a vital step in our OMS 7-step recovery plan and we want as many people to benefit from this information as possible. This is because research has shown that people with MS have lower levels of vitamin D, and also that vitamin D levels are lower during MS relapses. So not only has vitamin D been linked to preventing MS, but for people with MS, vitamin D offers numerous health benefits.

The Benefits of Vitamin D for MS

OMS recommends that your vitamin D level should be above 150nmol/L (60ng/mL in the USA). 

OMS recommends people with MS may need to take a daily vitamin D3 supplement, depending on the amount of sun they receive. For those with low levels at first testing, a one-off high dose of vitamin D (such as 600,000 IU), prescribed by a doctor, is recommended. 

What is the Coimbra Protocol?

The Coimbra Protocol is a high dose vitamin D treatment that was first discovered by Dr Cicero Galli Coimbra, a professor of Neurology at the Federal University of São Paulo, Brazil.

The dosage of vitamin D is high because people with autoimmune disorders such as MS require higher levels of vitamin D to overcome the resistance to vitamin D that MS will be maintaining. Taking high doses of vitamin D allows the cells and tissues of the body to function optimally.

Coimbra Protocol Side Effects

Whilst it is used as a treatment by many pwMS, it is important to note that the recommendations within the Comibra protocol at present are not backed up by published medical evidence. OMS does not endorse the Coimbra vitamin D doses, and there is the potential for complications from taking very high doses of vitamin D. The information on this page is for reference purposes only.  If the evidence base behind vitamin D changes, we will of course adjust our own recommendations accordingly.

How effective is the Coimbra Protocol for treating MS?

The protocol claims to have successfully suppressed disease activity in about 95% of those MS cases treated. Symptoms of MS fatigue are said to start to decline after one month of starting treatment and may continue to improve. It then takes approximately 7–9 months to stop MS progression according to Dr Coimbra’s experience with thousands of patients. Many people with MS claim to have experienced results with the Coimbra Protocol.

The treatment has to be given by a medical professional who has been trained in the Coimbra Protocol — you can’t self-treat with this protocol.

What is the dosage?

The dosage starts at around 1,000 IU per day, per kg of body weight. The dose of vitamin D is then adjusted after two or three months as needed. The dose is adjusted again after a year to compensate for adaptive changes of vitamin D metabolism and a stable level is found. After around two years on vitamin D therapy you will have reached your optimum level of vitamin D. 

Different patients will require different doses of vitamin D and at each appointment the person’s parathyroid hormone (PTH) level will be checked via a blood test to adjust the level of vitamin D. This is measured because vitamin D inhibits the production of PTH.  PTH cannot be completely suppressed as it has its own important functions within the body, so PTH levels are kept at their lowest normal limit for each individual. 

What are the dietary restrictions for the Coimbra Protocol?

While receiving treatment via the Coimbra Protocol, you need to follow strict dietary restrictions.

  • Vitamin D helps the absorption of calcium so it is important to avoid dairy foods, nuts and seeds as they are high in calcium. Too much calcium in your blood can lead to hypercalcemia which can create kidney stones, weaken your bones and cause problems with how your brain and heart function.

In addition, the OMS diet strongly recommends that people with MS avoid dairy altogether

  • You must also drink extra fluids, with a minimum of 2.5 litres of water per day to protect your kidneys by flushing your body and avoid excessive calcium in the body.
  • You must also limit your alcohol intake (one or two glasses a week is fine) as otherwise the alcohol can interfere with the vitamin D absorption.

Coimbra Protocol supplements

Along with this high dose of vitamin D you will be prescribed other supplements that will help absorption of the vitamin D such as omega-3 DHA, vitamin B2 and magnesium.

Dr. Coimbra also encourages a positive mindset and stress reduction techniques such as meditation to promote healing. This all ties in with our OMS 7-step recovery plan

The Coimbra protocol prescribes the patients to exercise daily. The intention behind this measure is to minimize the effects of the speeding up of the bone metabolism caused by the high dose of vit. D and avoid loss of bones mass. Those who cannot practice aerobic exercise might be advised to consider medication, such as bisphosphonates, to prevent osteoporosis.

Vitamin D
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Dimi (not verified)

I have been on the Coimbra Protocol since May 2019 with great results so far. It requires discipline to keep to the dietary requirements and the daily water intake. I have also been doing the OMS since 2018 and both OMS and Coimbra Protocol work nicely together. Thank you for spreading the word! More people should have the option to chose what is best for them and their own health.


I am so happy, that I found the Coimbra Protocol. Most of my MS symptoms are gone. Thank you Dr. Coimbra

Jean Lawson (not verified)

Thank you OMS for getting the word out. The Coimbra Protocol has helped me so much. My last MRI showed no new lesions and no activity. If you visit & join the Facebook Group "Coimbra Protocol North America", do a search for #Progress and you'll find lots of testimonials for MS and other autoimmune diseases. Patients are thanking Dr. Coimbra for giving them their lives back. He is a brilliant, humble, renowned Neurologist in Brazil who has been treating autoimmune diseases for over 15 years with great success. He teaches other doctors around the world for free on how to monitor patients on the protocol. Long live Dr. Coimbra.

Christina Kiening (not verified)

I am one of many thousand patients worldwide that are being successfully treated with the coimbra protocol. Not only did it stop my highly active and aggressive MS within only 8 months. But I have seen tremendous healing and recovered from my worst symptoms.

It has been four years now and I am still seeing improvements and also my MRIs have improved: Leasions have visible shrunken, younger ones disappeared completely, no new once since the beginning of treatment. Even my spinal cord has visibly regained volume and symptoms have faded accordingly.

God bless Dr. Cicero Coimbra - he is heaven sent!
For more information see www, or (both sites are non-profit projects of protocol patients).

Kalil F S Souza (not verified)

I am one patient of this protocol for autoimmune diseases, treating MS for almost 3 years, it is the best thing I could accept as my treatment

Anonymous (not verified)

I’m following OMS for 8 years and Coimbra Protocol for 18 months now. It’s working for me. Coimbra Protocol is still considered anecdotal and as such does not fall into a list of OMS recommendations. I’m taking a calculated risk but, being under doctor supervision, I feel safe and see progress. I think, at its beginnings, OMS was an unorthodox way of dealing with MS aso though it never did carry risks, just potential benefits.

Sarah Droms

I got my RRMS diagnosis in Jun 2018, started OMS in Jul 2018 (inc Copaxone) en Coimbra protocol in May 2019. I am very happy with this combination and think that OMS and Coimbra protocol go well together. I had a very dramatic start with MS with 2 relapses during the first 8 months with lots of lesions in my spine and a lot of sensory and motor symptoms and a lot of fatigue. All my symptoms are gone and my MRIs from Jul 2019 and Mar 2020 show no new lesions and the old ones getting smaller. I am so grateful to both Prof Jelinek and Prof Coimbra as well as all the wonderful people spreading the word about these treatments.

Petrice Durocher (not verified)

I’ve been following the OMS lifestyle and taking high doses of vitamin D for 11yrs. This article says to keep alcohol to 1-2 glasses/week. The OMS lifestyle suggests a glass of red wine 5x’s/week. So not sure which to follow??


Hi Petrice - this is only applicable if you are following Coimbra Protocol. So carry on with the usual recommendations for alcochol intake which should be in line with general advice e.g. NHS guidlines if you are in the UK

M M A (not verified)

it works!
I am able to do sports at a high level and had no flareups that I was aware of for more than 3 years now.
It it wonderful! very grateful! ?‍♂️

Anonymous (not verified)

Why no hot baths? He says that is part of protocal! What does hot baths do to ms patients ?

Anne Jamieson (not verified)

Patients on high dose Vitamin D, mostly do not have any heat intolerance, therefore do not feel tired, etc by overheating.But the abrupt change in temperature can be interpreted by the bodyas a fever, and activate the immune system. (From Ana Claudia Domene's book, "Multiple Sclerosis and (lots of) Vitamin D. ") Excellent book, btw, if you are interested in the Coimbra Protocol.

Dmitriy (not verified)

Does the Coimbra Protocol really help everyone?
I have not met any negative reviews. It happens?
I have MS. I think try the protocol.


Hi Dmitriy, please ensure you speak to someone before undertaking, the treatment has to be given by a medical professional who has been trained in the Coimbra Protocol — you can’t self-treat with this protocol.

MJ (not verified)

Coimbra 2 years plus Forks over Knives 2 years. Dr. Tressa Pinkelton is my Autoimmune specialist in Seattle Washington. She is Coimbra trained. She went to Brazil and trained in person with Dr. Coimbra. Must follow the Coimbra diet in regard to calcium uptake to be safe. Exercise regularly and limit alcohol. Forks over knives proves that food choices are one of the most powerful therapies. I could only make it from chair to chair for a couple of years before Coimbra. If you follow a healthy lifestyle with Coimbra you can end up running sprints uphill. I am 60yrs of age....Just make sure you do not do this on your own. You need a doctor to monitor your health. Side effects? None to date....


MJ (not verified)

My therapy started with 150,000 IU of Vitamin D daily with supplements to aid in Vit D absorption. Lab lab work every 3 months to check kidneys and blood for calcium uptake. No side effects and I did end up being able to run sprints up hill. Prior to that I could barely function. Vit D is and inexpensive therapy. Make sure you do not do this on your own, you can damage your kidneys. I do 2 liters of water daily. You have to do weight bearing exercises a couple of times a week to prevent osteoporosis. Walking running, lifting weights or whatever suits you. Last time I checked there were only 5 Coimbra trained docs in the US. I got lucky by living in WA State. Some neurologist's are supportive of this therapy. You may need to educate them on the procedure. I am now on 80,000 IU a day Vit D with supplements. I have zero side effects. I wish you all the best.


James Evans (not verified)

Coimbra doesn’t work for everyone. Followed it for 2.5 years, and zero effect. Been following OMS for three years five months and though no improvement they say 3-5 years to stabilise. Coimbra claims 2-3 months after pth normal minimum and one year symptoms vanish. Not true. After five months minimum normal pth I’m reducing D3 intake because although it’s remained stable it hasn’t improved so I’ll stick with Jelinek which is safer and encourages normal alcohol intake.


rocio (not verified)

i am medical doctor. I am interested in learn about vitamine D.

James Evans (not verified)

George Jelinek is biased against supplements. He seems to think toxic drugs like copaxone and Gilenya are better! Nonsense!

That view is based on poor quality studies ( no doubt funded by pharmaceutical companies), that vitamins are dangerous. That’s untrue. Of course choose high quality supplements.

One major cause of relapses under both OMS and Coimbra is UTIs. These are proven to be prevented by high doses Vitamin C.

Read Linus Pauling: How To Live Longer And Feel Better (only scientist who won two Nobel Prizes!) suggest 15000mg vitamin C and 25,000 iu vitamin A plus 1000iu vitamin E. Vitamin C is natural source of interferons. Vitamin A reverses autoimmune disease. B3 is standard essential treatment for autoimmune disease in Klenner protocol.

Check your facts Professor Jelinek. Claims that these vitamins are dangerous are NONSENSE!

So if you have been following OMS or Coimbra for three years without results, add 40,000D3 (10,000iu is too low), with 2.5 litres water and minimal calcium to protect kidney function, plus one 25,000iu vitamin A a day, plus 1000iu vitamin E, plus 4500mg liposomal vitamin C and 3000mg plus good quality vitamin C tablets or powder. Try for a month and you will notice improvement. Dr Klenner prescribed 17,000mg vitamin C plus vitamin A and B1 and B3. Look his protocol up! Try it. Just bear in mind he advised injections of B1 due to biased studies that B1 is not well absorbed orally. That’s been shown to be false.

Also, look at Dr Michael Caswon -verified Coimbra protocol dr- who says most people he treated on standard Coimbra protocol went backwards, and pth was Not a good indicator of success! I agree and after six months minimum pth normal reference, decided it was wrong. Now I have 45,000iu D3 with (40,000 iu healthy origins) and Life Extension D3 5000iu and 2000mg Vitamin K plus Fish oil (Now Foods)- contrary to professor Jelinek, Erasmus gives no support for flax oil over fish oil. Many studies show fish oil (good quality), gives direct EPA DPA, unlike flax oil which is poorly converted. Plus flax oil is expensive and awful tasting! Does Professor Jelinek own shares in Stoney Creek Oil?

Izabel (not verified)

Where would I find a Coimbra Protocol doctor who would work with the Australian time zone? I'm in Adelaide and would like to find out more. Thanks

Isabelle (not verified)

Forgot i messaged here. Follow up is a US friend with MS connected me to the North America CP fb group and i found some CP doctors who do Skype sessions from Europe and have just booked my first appointment.