Progressive Relapsing MS – PRMS

What is Progressive Relapsing MS (PRMS)?

PRMS is the least common type of multiple sclerosis. It is estimated that only 5% of people with MS have PRMS.

In this uncommon form of MS, people experience both progressive neurological decline with increasing disability, and also attacks or relapses.  PRMS is often misdiagnosed as primary progressive MS (PPMS) until the relapses start.

In addition to the more common MS symptoms, people with PRMS will typically experience a continuous decrease in mobility, with occasional, noticeable attacks such as sudden weakness of an arm or leg, visual disturbance, or sensory symptoms. 

PRMS affects men and women equally and people with PRMS tend to be diagnosed in their mid-to-late 30s.

As you can see from our graph, people with progressive relapsing MS (PRMS) experience both progressive neurological decline and attacks.

Symptoms of Progressive Relapsing MS

Symptoms of progressive relapsing MS are similar to primary progressive MS. The following symptoms may be felt and can progress over time:

• Muscle spasms or weakness
• Fatigue
• Problems with memory and focusing
• Vision problems
• Numbness and tingling
• Difficulty walking
• Bladder spasms or bowel problems
• Pain
• Sexual problems
• Depression